Year: 2016 | Month: December | Volume 5 | Issue 2
Waldenstrom macroglobulinemia- Diagnostic dilemma in hemato-oncology
Abstract:
Macroglobulinemia refers to the excess production of IgM monoclonal protein that occurs in certain lymphoproliferative disorders and plasma cell dyscrasias. This broad definition includes patients with monoclonal gammopathy of undetermined significance of the IgM type (IgM MGUS), smoldering Waldenström macroglobulinemia (SWM), Waldenström macroglobulinemia (WM), and a number of related disorders in which an IgM monoclonal protein is detected, such as chronic lymphocytic leukemia (CLL), a number of lymphoma variants, and primary (AL) amyloidosis.WM is a diagnosed by demonstrating lymphoplasmacytic lymphoma (LPL) in the bone marrow with an IgM monoclonal gammopathy in the blood. Infiltration of the hematopoietic tissues or the effects of monoclonal IgM in the blood causes the symptoms associated with disorder.
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